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KMID : 0043320110340050709
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Archives of Pharmacal Research
2011 Volume.34 No. 5 p.709 ~ p.714
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Modiolide and pyrone derivatives from the sea fan-derived fungus Curvularia sp. PSU-F22
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Trisuwan Kongkiat
Rukachaisirikul Vatcharin
Phongpaichit Souwalak
Preedanon Sita
Sakayaroj Jariya
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Abstract
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Investigation of secondary metabolites from the sea fan-derived fungus Curvularia sp. PSU-F22 resulted in isolation of three new metabolites, curvulapyrone (1), curvulalide (2) and curvulalic acid (3) together with six known compounds, modiolides A (4) and B (5), pyrenolide A (6), stagonolide E (7), mycoepoxydiene (8), and deacetylmycoepoxydiene (9). Their antimicrobial activity against Staphylococcus aureus ATCC 25923, methicillin-resistant S. aureus and Microsporum gypseum SH-MU-4 were examined.
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KEYWORD
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Curvularia sp., Sea fan-derived, fungus, Modiolide, Pyrone, Mycoepoxydiene, Antibacterial activity, Antifungal activity
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